Invitrogen

Sortilin Monoclonal Antibody (CL6528)

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他16个Sortilin抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

高级验证 (1)

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Sortilin Antibody (MA5-31438)

Relative expression in different tissues in IHC: Detection of differential expression levels of Sortilin demonstrates antibody specificity. Immunohistochemical analysis of Sortilin using anti-Sortilin Monoclonal Antibody (CL6528) (Product #MA5-31438), shows significant staining of Sortilin in cerebral cortex and shows minimal or weak staining in tonsil tissues. The relative expression levels of Sortilin wi... View More

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产品信息

MA5-31438

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

免疫组化 (IHC)

1:200-1:500

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CL6528

抗原

Recombinant protein corresponding to Human SORT1

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2787074

产品详细信息

Immunogen sequence: LERNCEEKDY TIWLAHSTDP EDYEDGCILG YKEQFLRLRK SSVCQNGRDY VVTKQPSICL CSLEDFLCDF GYYRPENDSK CVEQPELKGH DLEFCLYGRE EHLTTNGYRK IPGDKCQGGV NPVREVKD

靶标信息

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。