Alomone Labs, LTD

Sortilin (extracellular) Polyclonal Antibody, FITC

Sortilin (extracellular) Antibody in Flow Cytometry (Flow)

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Sortilin (extracellular) Antibody (ANT-009-F-50UL) in Flow

Cell surface detection of Sortilin inlive intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-Sortilin (extracellular)-FITC Antibody (#ANT-009-F), (2.5 µg).

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产品信息

ANT-009-F-50UL

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

2.5 µg

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

DKDTTRRIHVSTDQD(C) corresponding to amino acid residues 320-335 of human Sortilin, Extracellular domain

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偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。