Proteintech

Spartin/SPG20 Polyclonal Antibody

Spartin/SPG20 Antibody in Immunocytochemistry (ICC/IF)

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Spartin/SPG20 Antibody (13791-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using SPG20 antibody 13791-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

Spartin/SPG20 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Spartin/SPG20 Antibody in Western Blot (WB)

Spartin/SPG20 Antibody in Flow Cytometry (Flow)

Spartin/SPG20 Antibody in Immunoprecipitation (IP)

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产品信息

13791-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看10篇已发表文章 10篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:10-1:100

查看5篇已发表文章 5篇已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Spartin, SPG20 Fusion Protein Ag4815 (1-350 aa encoded by BC047083)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.15 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MEQEPQNGE PAEIKIIREA YKKAFLFVNK GLNTDELGQK EEAKNYYKQG IGHLLRGISI SSKESEHTGT GWESARQMQQ KMKETLQNVR TRLEILEKGL ATSLQNDLQE VPKLYPEFPP KDMCEKLPEP QSFSSAPQHA EVNGNTSTPS AGAVAAPASL SLPSQSCPAE APPAYTPQAA EGHYTVSYGT DSGEFSSVGE EFYRNHSQPP PLETLGLDAD ELILIPNGVQ IFFVNPAGEV SAPSYPGYLR IVRFLDNSLD TVLNRPPGFL QVCDWLYPLV PDRSPVLKCT AGAYMFPDTM LQAAGCFVGV VLSSELPEDD RELFEDLLRQ MSDLRLQANW NRAEEENEFQ I (1-350 aa encoded by BC047083)

靶标信息

SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Novel Homozygous Missense Mutation in SPG20 Gene Results in Troyer Syndrome Associated with Mitochondrial Cytochrome c Oxidase Deficiency.

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Germline deletion of huntingtin causes male infertility and arrested spermiogenesis in mice.

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Tue May 05 00:00:00 EDT 2015

Chromosome mis-segregation and cytokinesis failure in trisomic human cells.

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生物信息学

蛋白别名: Spartin; spastic paraplegia 20 (Troyer syndrome) homolog; Spastic paraplegia 20 protein; spastic paraplegia 20, spartin (Troyer syndrome) homolog; Trans-activated by hepatitis C virus core protein 1

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基因别名: AI840044; C79168; KIAA0610; mKIAA0610; SPART; SPARTIN; SPG20; TAHCCP1

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UniProt ID: (Human) Q8N0X7, (Mouse) Q8R1X6

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Entrez Gene ID: (Human) 23111, (Rat) 295053, (Mouse) 229285

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功能

protein binding ubiquitin protein ligase binding

参与通路

abscission negative regulation of BMP signaling pathway lipid particle organization negative regulation of collateral sprouting in absence of injury neuromuscular process cell division regulation of mitochondrial membrane potential adipose tissue development cytokinesis