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NeoBiotechnologies
StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker) Recombinant Rabbit Monoclonal Antibody (STAR/3915R)
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StAR (Steroidogenic Acute Regulator) (Leydig Cell Marker) Antibody (6770-RBM5-P0) in IHC (P)
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Star Recombinant Rabbit Monoclonal Antibody (STAR/3915R). HIER: Tris/EDTA, pH9.0, 45 min. 2 °: HRP-polymer, 30 min. DAB, 5 min.
产品信息
6770-RBM5-P0
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
STAR/3915R
抗原
Recombinant fragment (around aa 39-108) of human STAR protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Wet ice
靶标信息
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cholesterol trafficker; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP
基因别名: STAR; STARD1
UniProt ID: (Human) P49675
Entrez Gene ID: (Human) 6770
steroid biosynthetic process
bile acid biosynthetic process
C21-steroid hormone biosynthetic process
progesterone biosynthetic process
estrogen biosynthetic process
brain development
response to nutrient
cholesterol metabolic process
glucocorticoid metabolic process
male gonad development
response to herbicide
response to ionizing radiation
response to lead ion
positive regulation of gene expression
response to activity
diterpenoid metabolic process
insecticide metabolic process
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
intracellular cholesterol transport
cellular response to insulin stimulus
response to nicotine
cellular response to interferon-alpha
response to drug
response to hydrogen peroxide
circadian sleep/wake cycle, REM sleep
negative regulation of neuron apoptotic process
response to estrogen
response to leptin
cellular response to fibroblast growth factor stimulus
response to ethanol
regulation of neuronal synaptic plasticity
positive regulation of neurogenesis
response to corticosterone
response to fungicide
testosterone biosynthetic process
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to cadmium ion
cellular response to alkaloid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to interferon-gamma
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to growth hormone stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to epinephrine stimulus
