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Invitrogen
Synapsin 1 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Synapsin 1 Antibody (OPA1-04001) in WB
Western blot was performed using anti-Synapsin1 Polyclonal Antibody (Product # OPA1-04001) and 78 kDa band corresponding to Synapsin1 was observed across cell lines and tissues tested except Mouse and Rat Lung, Mouse Heart and Raji which are reported to be negative. Whole cell Extracts of (30 µg lysate) of IMR-32 (Lane 1), PC-12 (Lane 2), Raji (Lane 8), tissue extracts of Mouse Brain (Lane 3), Rat Brain (Lane 4), Mouse Lung (Lane 5), Rat Lung (Lane 6) and Mouse Heart (Lane 7) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (P... View More
产品信息
OPA1-04001
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Native protein purified from bovine brain
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_325645
产品详细信息
In Western blot, this antibody detects an ~77 kDa and ~80 kDa protein representing synapsin I alpha and synapsin I beta respectively, in rat brain homogenate. Immunohistochemical staining of synapsin 1 alpha and 1 beta in human brain with OPA1-04001 yields a pattern consistent with cytoplasmic vesicle staining.
靶标信息
SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Brain protein 4.1; synapsin 1; Synapsin I; Synapsin-1; truncated synapsin 1-S
基因别名: Syn-1; SYN1; Syn1-S; SYN1a; SYN1b; SYNI
UniProt ID: (Bovine) P17599, (Human) P17600, (Rat) P09951, (Mouse) O88935
Entrez Gene ID: (Bovine) 281510, (Human) 6853, (Rat) 24949, (Mouse) 20964
