Immunogen sequence: APQQPPKAR TGISKPYNVK QIKTTNAQEA EAAIRCLLEA RGGASEEALS AVAPRDLEAS SEPEPTPGAA KPETPQAPPL LPRRPPPRVP AIKKPTLRRT GKPLSPEEQF EQQTVHFTIG PPETSVEAPP VVTAPRVPPV PKPRTFQPGK AAERPSHRKP ASDEAPPGAG ASVPPPLEAP PLVPKVPPRR KKSAPAAFHL QVLQSNSQLL QGLTYNSSDS PSGHPPAAGT VFPQGDFLST SSATSPDSDG TKAMKPEAAP LLGDYQDPFW NLLHHPKLLN NTWLSKSSDP LDSGTRSPKR DPIDPVSAGA SAAKAELPPD HGHKTLGHWV TISDQEKRTA LQVFDPLAKT (1147-1496 aa encoded by BC043277)
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: inositol phosphate 5'-phosphatase 2; inositol polyphosphate-5-phosphatase H; phosphoinositide 5-phosphatase; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2; Synaptojanin-2
基因别名: AI481647; INPP5H; KIAA0348; mKIAA0348; SJ2; SYNJ2
UniProt ID: (Human) O15056, (Mouse) Q9D2G5, (Rat) O55207
Entrez Gene ID: (Human) 8871, (Mouse) 20975, (Rat) 84018
分子生物学功能:
phosphatase