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Immunogen sequence: WIEEECHRV EAQLALKEAR KEIKQLKQVI DTVKNNLIDK DKGLQKYFVD INIQNKKLET LLHSMEVAQN GMAKEDGTGE SAGGSPARSL TRSSTYTKLS DPAVCGDRQP GDPSSGSAED GADSGFAAAD DTLSRTDALE ASSLLSSGVD CGTEETSLHS SFGLGPRFPA SNTYEKLLCG MEAGVQASCM QERAIQTDFV QYQPDLDTIL EKVTQAQVCG TDPESGDRCP ELDAHPSGPR DPNSAVVVTV GDELEAPEPI TRGPTPQRPG ANPNPGQSVS VVCPMEEEEE AAVAEKEPKS YWSRH (121-424 aa encoded by BC035788)
Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bA314N13.5; Syntaphilin
基因别名: 6430515A01; AW045671; AW556958; AW743098; KIAA0374; mKIAA0374; SNPH
UniProt ID: (Human) O15079, (Rat) B5DF41, (Mouse) Q80U23
Entrez Gene ID: (Human) 9751, (Rat) 296267, (Mouse) 241727
分子生物学功能:
SNARE protein