Invitrogen

TACR1 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

1个已发表图片

2 篇参考文献

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

TACR1 Antibody in Immunocytochemistry (ICC/IF)

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TACR1 Antibody (PA1-32229) in ICC/IF

Immunofluorescence analysis of TACR1 was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with TACR1 Polyclonal Antibody (Product PA1-32229) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then with Goat anti-Rabbit IgG (Heavy Chain), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488 (Product # A27034, 1:20... View More

TACR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TACR1 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines owing to their inherent genetic constitution. TACR1 is expressed in higher levels in Panc-1 in comparison to MIA PaCa-2, MCF7 and MDA-MB-231 in comparison to SK-BR-3 and in NIH:OVCAR-3 in comparison to SK0OV-3 using TACR1 Polyclonal Antibody (Product # PA1-32229) in Western Blot. {RE}

产品信息

PA1-32229

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:100-1:2,000

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免疫组化（石蜡） (IHC (P))

Assay-dependent

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免疫组化（冰冻） (IHC (F))

1:1,000

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Dog, Guinea pig, Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Was raised against a synthetic peptide at the c-terminus of rat NK-1 conjugated to bovine thyroglobulin.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1958927

产品详细信息

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Activation of neuroimmune pathways increases therapeutic effects of radiotherapy on poorly differentiated breast carcinoma.

Brain, behavior, and immunity

Erin N,Korcum AF,Tanrıöver G,Kale Ş,Demir N,Köksoy S

PA1-32229 was used in western blot to study the effects of continuous exposure to low doses of substance P on metastatic breast cancer

Sat Aug 01 00:00:00 EDT 2015

Identification of clinical target areas in the brainstem of prion-infected mice.

Neuropathology and applied neurobiology

Mirabile I,Jat PS,Brandner S,Collinge J

PA1-32229 was used in immunohistochemistry - paraffin section to investigate prion infection in different areas of the brain

Sat Aug 01 00:00:00 EDT 2015

生物信息学

蛋白别名: neurokinin 1 receptor; neurokinin receptor 1; neurokinin receptor subtype NK1; neurokinin-1 receptor; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

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基因别名: NK1R; NKIR; SPR; TAC1R; TACR1