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TACR1 Antibody (PA5-18712) in ICC/IF
Immunocytochemistry analysis of TACR1 using TACR1 Polyclonal Antibody (Product # PA5-18712) in paraformaldehyde fixed Neuro2a cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and plasma membrane staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-18712
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (EIPGDSSDRYHEQ) corresponding to the internal amino acids of TACR1 (aa 227-240).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10984223
产品详细信息
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
靶标信息
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
基因别名: NK1R; NKIR; SPR; TAC1R; TACR1
UniProt ID: (Human) P25103, (Mouse) P30548
Entrez Gene ID: (Human) 6869, (Mouse) 21336
aggressive behavior
acute inflammatory response
positive regulation of leukocyte migration
angiotensin-mediated drinking behavior
inflammatory response
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
chemical synaptic transmission
long-term memory
associative learning
response to heat
detection of abiotic stimulus
response to ozone
positive regulation of epithelial cell migration
response to auditory stimulus
regulation of smooth muscle cell migration
sensory perception of pain
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to estradiol
response to progesterone
response to nicotine
operant conditioning
positive regulation of renal sodium excretion
sperm ejaculation
eating behavior
positive regulation of vascular permeability
response to morphine
response to ethanol
positive regulation of action potential
positive regulation of blood pressure
positive regulation of ossification
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
positive regulation of saliva secretion
positive regulation of hormone secretion
behavioral response to pain
regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of epithelial cell proliferation
positive regulation of stress fiber assembly
response to electrical stimulus
smooth muscle contraction involved in micturition
positive regulation of uterine smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
learning or memory
regulation of blood pressure
response to hormone
response to organic cyclic compound
response to pain
