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产品信息
PA5-142408
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-QKFREKLQEIKT.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933056
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
靶标信息
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
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生物信息学
蛋白别名: ABC transporter, MHC 1; Antigen peptide transporter 1; AOI; APT1; ATP-binding cassette sub-family B member 2; ATP-binding cassette, sub-family B (MDR/TAP), member 2; beta-filamin; DAAP-57C1.5; FH1; filamin homolog 1; filamin-3; filamin-B; FLJ26666; FLJ41500; FLN1L; LRS1; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; Really interesting new gene 4 protein; RING4; TABP; tap i; thyroid autoantigen; transporter 1 ATP-binding cassette sub-family B; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter, ATP-binding cassette, major histocompatibility complex, 1
基因别名: ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1; TAP1*0102N; TAP1N; Y3
UniProt ID: (Human) Q03518
Entrez Gene ID: (Human) 6890
protein binding
ATP binding
peptide transporter activity
peptide-transporting ATPase activity
MHC class Ib protein binding
MHC class I protein binding
peptide antigen binding
ATPase activity, coupled to transmembrane movement of substances
protein homodimerization activity
ADP binding
TAP1 binding
TAP2 binding
tapasin binding
protein heterodimerization activity
ATP-binding cassette (ABC) transporter
adaptive immune response
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
defense response
peptide transport
intracellular transport of viral protein in host cell
antigen processing and presentation of endogenous peptide antigen via MHC class I
protection from natural killer cell mediated cytotoxicity
cytosol to ER transport
transmembrane transport
