Proteintech

TAZ Polyclonal Antibody

TAZ Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TAZ Antibody (23306-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 23306-1-AP ( WWTR1,TAZ Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

TAZ Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

23306-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000-1:4,000

查看30篇已发表文章 30篇已发表文章

免疫组化 (IHC)

查看9篇已发表文章 9篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫细胞化学 (ICC/IF)

查看5篇已发表文章 5篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看4篇已发表文章 4篇已发表文章

染色质免疫沉淀实验 (ChIP)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

TAZ Fusion Protein Ag19659 (1-400 aa encoded by BC014052)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.46 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MNPASAPPP LPPPGQQVIH VTQDLDTDLE ALFNSVMNPK PSSWRKKILP ESFFKEPDSG SHSRQSSTDS SGGHPGPRLA GGAQHVRSHS SPASLQLGTG AGAAGSPAQQ HAHLRQQSYD VTDELPLPPG WEMTFTATGQ RYFLNHIEKI TTWQDPRKAM NQPLNHMNLH PAVSSTPVPQ RSMAVSQPNL VMNHQHQQQM APSTLSQQNH PTQNPPAGLM SMPNALTTQQ QQQQKLRLQR IQMERERIRM RQEELMRQEA ALCRQLPMEA ETLAPVQAAV NPPTMTPDMR SITNNSSDPF LNGGPYHSRE QSTDSGLGLG CYSVPTTPED FLSNVDEMDT GENAGQTPMN INPQQTRFPD FLDCLPGTNV DLGTLESEDL IPLFNDVESA LNKSEPFLTW L (1-400 aa encoded by BC014052)

靶标信息

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

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Fri Jan 06 00:00:00 EST 2023

TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.

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Fri Jan 06 00:00:00 EST 2023

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA).

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USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.

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USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.

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PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ.

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PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ.

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PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ.

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PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ.

Cell death & disease

Yang Q,Lu Y,Shangguan J,Shu X

Wed Nov 23 00:00:00 EST 2022

PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ.

Cell death & disease

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Wed Nov 23 00:00:00 EST 2022

A positive feedback loop of the TAZ/β-catenin axis promotes Helicobacter pylori-associated gastric carcinogenesis.

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Wed Jan 11 00:00:00 EST 2023

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Glia

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Piezo channels contribute to the regulation of myelination in Schwann cells.

Glia

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WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Cancers

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USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ.

Cell death & disease

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Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.

Respiratory research

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Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.

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Tue May 02 00:00:00 EDT 2023

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CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.

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YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration.

Glia

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Thu Apr 01 00:00:00 EDT 2021

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Mon Feb 01 00:00:00 EST 2021

TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling.

Bone research

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Mon Jul 12 00:00:00 EDT 2021

TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling.

Bone research

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Mon Jul 12 00:00:00 EDT 2021

The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.

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TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.

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Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway.

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Yuan L,Zhou M,Wasan HS,Zhang K,Li Z,Guo K,Shen F,Shen M,Ruan S

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Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

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Mon Feb 12 00:00:00 EST 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer cell

Wu LMN,Deng Y,Wang J,Zhao C,Wang J,Rao R,Xu L,Zhou W,Choi K,Rizvi TA,Remke M,Rubin JB,Johnson RL,Carroll TJ,Stemmer-Rachamimov AO,Wu J,Zheng Y,Xin M,Ratner N,Lu QR

Mon Feb 12 00:00:00 EST 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer cell

Wu LMN,Deng Y,Wang J,Zhao C,Wang J,Rao R,Xu L,Zhou W,Choi K,Rizvi TA,Remke M,Rubin JB,Johnson RL,Carroll TJ,Stemmer-Rachamimov AO,Wu J,Zheng Y,Xin M,Ratner N,Lu QR

Mon Feb 12 00:00:00 EST 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer cell

Wu LMN,Deng Y,Wang J,Zhao C,Wang J,Rao R,Xu L,Zhou W,Choi K,Rizvi TA,Remke M,Rubin JB,Johnson RL,Carroll TJ,Stemmer-Rachamimov AO,Wu J,Zheng Y,Xin M,Ratner N,Lu QR

Mon Feb 12 00:00:00 EST 2018

MicroRNA-144 inhibits proliferation by targeting WW domain-containing transcription regulator protein 1 in papillary thyroid cancer.

Oncology letters

Sun W,Lan X,Wang Z,Dong W,He L,Zhang T,Zhang P,Zhang H

Mon Jan 01 00:00:00 EST 2018

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Nature neuroscience

Poitelon Y,Lopez-Anido C,Catignas K,Berti C,Palmisano M,Williamson C,Ameroso D,Abiko K,Hwang Y,Gregorieff A,Wrana JL,Asmani M,Zhao R,Sim FJ,Wrabetz L,Svaren J,Feltri ML

Fri Jul 01 00:00:00 EDT 2016

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Nature neuroscience

Poitelon Y,Lopez-Anido C,Catignas K,Berti C,Palmisano M,Williamson C,Ameroso D,Abiko K,Hwang Y,Gregorieff A,Wrana JL,Asmani M,Zhao R,Sim FJ,Wrabetz L,Svaren J,Feltri ML

Fri Jul 01 00:00:00 EDT 2016

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Nature neuroscience

Poitelon Y,Lopez-Anido C,Catignas K,Berti C,Palmisano M,Williamson C,Ameroso D,Abiko K,Hwang Y,Gregorieff A,Wrana JL,Asmani M,Zhao R,Sim FJ,Wrabetz L,Svaren J,Feltri ML

Fri Jul 01 00:00:00 EDT 2016

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Nature neuroscience

Poitelon Y,Lopez-Anido C,Catignas K,Berti C,Palmisano M,Williamson C,Ameroso D,Abiko K,Hwang Y,Gregorieff A,Wrana JL,Asmani M,Zhao R,Sim FJ,Wrabetz L,Svaren J,Feltri ML

Fri Jul 01 00:00:00 EDT 2016

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.

Oncogene

Li L,Fang R,Liu B,Shi H,Wang Y,Zhang W,Zhang X,Ye L

Thu Aug 04 00:00:00 EDT 2016

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.

Oncogene

Li L,Fang R,Liu B,Shi H,Wang Y,Zhang W,Zhang X,Ye L

Thu Aug 04 00:00:00 EDT 2016

生物信息学

蛋白别名: DKFZp586I1419; FLJ27004; FLJ45718; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain-containing transcription regulator protein 1

查看更多收起

基因别名: TAZ; WWTR1

查看更多收起

UniProt ID: (Human) Q9GZV5

查看更多收起

Entrez Gene ID: (Human) 25937

查看更多收起

功能

transcription coactivator activity transcription corepressor activity protein binding protein homodimerization activity transcription cofactor

参与通路

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation negative regulation of protein phosphorylation regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter negative regulation of protein kinase activity positive regulation of cell proliferation positive regulation of epithelial to mesenchymal transition protein ubiquitination stem cell division SCF-dependent proteasomal ubiquitin-dependent protein catabolic process glomerulus development multicellular organism growth hippo signaling negative regulation of catenin import into nucleus negative regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter mesenchymal cell differentiation cilium morphogenesis regulation of SMAD protein import into nucleus kidney morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation negative regulation of canonical Wnt signaling pathway

TAZ Polyclonal Antibody

TAZ Antibody (23306-1-AP) in IHC (P)

产品信息

23306-1-AP

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

染色质免疫沉淀实验 (ChIP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

TAZ Polyclonal Antibody

TAZ Antibody (23306-1-AP) in IHC (P)

产品信息

23306-1-AP

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

染色质免疫沉淀 实验 (ChIP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

染色质免疫沉淀实验 (ChIP)