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TBK1 Antibody (MA5-16159) in IHC (P)
Immunohistochemical analysis of TBK1 in formalin-fixed paraffin-embedded human testis tissue section. Samples were incubated in TBK1 monoclonal antibody (Product # MA5-16159) using a dilution of 1:200. The staining was developed with HRP-DAB detection method and the counterstaining was performed using hematoxylin.
产品信息
MA5-16159
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
108A429
抗原
Synthetic peptide (YYQFKKDKAERRLAYC ) of TBK1/NAK protein.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2537678
产品详细信息
Suggested positive control: human testis protein, NIH-3T3 or RAW.
靶标信息
TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk
基因别名: 1200008B05Rik; AI462036; AW048562; FTDALS4; NAK; T2K; TBK1
UniProt ID: (Human) Q9UHD2, (Mouse) Q9WUN2
Entrez Gene ID: (Dog) 481145, (Human) 29110, (Bovine) 533141, (Mouse) 56480, (Rat) 299827
nucleic acid binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
phosphoprotein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
inflammatory response
I-kappaB kinase/NF-kappaB signaling
response to virus
negative regulation of gene expression
peptidyl-serine phosphorylation
negative regulation of type I interferon production
positive regulation of type I interferon production
type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of peptidyl-serine phosphorylation
TRIF-dependent toll-like receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
dendritic cell proliferation
innate immune response
positive regulation of interferon-beta biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
defense response to Gram-positive bacterium
defense response to virus
regulation of neuron death
positive regulation of xenophagy
activation of innate immune response
immune system process
protein phosphorylation
phosphorylation
