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TBX3 Monoclonal Antibody (8H3)

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抗体检测数据 (1)

TBX3 Antibody in Western Blot (WB)

TBX3 Antibody in Western Blot (WB)

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TBX3 Antibody (H00006926-M02) in WB

TBX3 monoclonal antibody (M02), clone 8H3. Western Blot analysis of TBX3 expression in PC-12.

TBX3 Antibody in Western Blot (WB)

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TBX3 Antibody in Western Blot (WB) — TBX3 monoclonal antibody (M02), clone 8H3. Western Blot analysis of TBX3 expression in PC-12.

产品信息

H00006926-M02

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫细胞化学 (ICC/IF)

10-100 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

8H3

抗原

TBX3 (NP_005987, 311 a.a. approximately 410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

Product may be used with Western Blot (Cell lysate).

Immunogen sequence: KENGTSDESS SEQAAFNCFA QASSPAASTV GTSNLKDLCP SEGESDAEAE SKEEHGPEAC DAAKISTTTS EEPCRDKGSP AVKAHLFAAE RPRDSGRLDK

靶标信息

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: bladder cancer related protein XHL; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3

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基因别名: D5Ertd189e; TBX3; TBX3-ISO; UMS; XHL

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UniProt ID: (Human) O15119, (Mouse) P70324, (Rat) Q7TST9

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Entrez Gene ID: (Human) 6926, (Mouse) 21386, (Rat) 353305

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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding protein binding sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding molecular_function Rel homology transcription factor

参与通路

negative regulation of transcription from RNA polymerase II promoter skeletal system development blood vessel development in utero embryonic development heart looping outflow tract morphogenesis atrioventricular bundle cell differentiation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell aging positive regulation of cell proliferation anterior/posterior axis specification, embryo organ morphogenesis specification of organ position stem cell population maintenance limbic system development male genitalia development female genitalia development negative regulation of epithelial cell differentiation mammary gland development luteinizing hormone secretion embryonic forelimb morphogenesis embryonic hindlimb morphogenesis forelimb morphogenesis embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of myoblast differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated follicle-stimulating hormone secretion mesoderm morphogenesis palate development ventricular septum morphogenesis branching involved in mammary gland duct morphogenesis mammary placode formation cardiac muscle cell fate commitment sinoatrial node cell development cellular senescence positive regulation of stem cell proliferation heart morphogenesis regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development embryonic heart tube development limb morphogenesis regulation of cell proliferation cardiac muscle cell differentiation