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Invitrogen
TCL1A Monoclonal Antibody (1 21)
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TCL1A Antibody (39-4800) in ICC/IF
Immunofluorescence analysis of TCL1A was performed using 90% confluent log phase KARPAS 299 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with TCL1A Monoclonal Antibody (1 21) (Product # 39-4800) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at... View More
产品信息
39-4800
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
1 21
抗原
Recombinant full-length human TCL-1A protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
靶标信息
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (summarized by Virgilio et al., 1998). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
