Invitrogen

TCP-1 theta Polyclonal Antibody

TCP-1 theta Antibody in Immunocytochemistry (ICC/IF)

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TCP-1 theta Antibody (PA5-97557) in ICC/IF

Immunofluorescent analysis of TCP-1 theta in MCF-7 cells using a TCP-1 theta polyclonal antibody (Product # PA5-97557) at a dilution of 1:100. Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) secondary antibody was used.

TCP-1 theta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TCP-1 theta Antibody in Western Blot (WB)

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产品信息

PA5-97557

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

Assay-Dependent

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Human T-complex protein 1 subunit theta protein (224-491AA)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

4 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.03% ProClin 300

保存条件

-20°C or -80°C if preferred

运输条件

Wet ice

RRID

AB_2812173

靶标信息

TCP-1 theta is theta subunit of the CCT (chaperonin containing TCP1 complex) chaperonin molecule which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of the newly synthesized proteins. Molecular chaperones assist in the protein folding upon ATP hydrolysis and TCP-1 theta may play a role in the assembly of the BBsome, a complex that is involved in ciliogenesis regulating transport vesicles to the cilia. Further, TCP-1 theta is also involved in the folding of actin and tubulin. The intact CCT complex is composed of eight polypeptides in a double ring structure. CCT is important within cells in the folding of the VHL tumor suppressor protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; chaperonin containing TCP1, subunit 8 (theta); chaperonin subunit 8 (theta); Renal carcinoma antigen NY-REN-15; T-complex protein 1 subunit theta; TCP-1-theta

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基因别名: AI132397; C21orf112; CCT8; CCTQ; D21S246; KIAA0002; PRED71; Tcpq

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UniProt ID: (Human) P50990, (Mouse) P42932

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Entrez Gene ID: (Human) 10694, (Mouse) 12469

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功能

protein binding ATP binding ATPase activity, coupled unfolded protein binding cadherin binding involved in cell-cell adhesion nucleotide binding chaperonin

参与通路

protein folding binding of sperm to zona pellucida positive regulation of telomere maintenance via telomerase pore complex assembly protein stabilization cell-cell adhesion toxin transport positive regulation of establishment of protein localization to telomere positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body