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产品信息
PA5-120213
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TEAD1 (NP_068780.2).
偶联物
形式
Liquid
浓度
2.16 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913785
产品详细信息
Positive test controls include: 293T, HeLa, Mouse skeletal muscle, Mouse heart, Rat heart. The target is usually found in the following locations: Nucleus.
Immunogen sequence: APSVPAWQGR SIGTTKLRLV EFSAFLEQQR DPDSYNKHLF VHIGHANHSY SDPLLESVDI RQIYDKFPEK KGGLKELFGK GPQNAFFLVK FWADLNCNIQ D
靶标信息
TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein that is expressed in numerous cell types and plays a role in controlling the expression of numerous genes. TEF family members have a highly conserved DNA-binding domain TEF-1 binds to GT-IIC, SphI/II and M-CAT. TEF-1 also binds to the proximal regulatory element (PRE) of transforming growth factor-alpha, a member of the EGF family that is overexpressed in many types of cancer. Furthermore, TEF-1 represses transcription in placental cells. In vitro, TEF-1 is phosphorylated by several PKC isozymes. TEF-1 is phosphorylated in vivo at serine and threonine residues. Phosphorylation of TEF-1, both in vivo and in vitro, results in a reduction in its DNA-binding capability, which suggests a potential role for TEF-1 in PKC inhibition. TEF-1 also complexes with larger tumor antigen (TAg), and may thus have a role in tumorigenesis. Dimerization of TEF-1 may be important for TEF-1 to function as a regulator of gene transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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