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TESK2 or testis-specific kinase 2 is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. The kinase domain of TESK2 is structurally similar to the kinase domain of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). TESK2 is predominantly expressed in testis and prostate and plays an important role in spermatogenesis. TESK2 phosphorylates cofilin specifically at Ser-3 and induces formation of actin stress fibers and focal adhesions.
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蛋白别名: Dual specificity testis-specific protein kinase 2; Testicular protein kinase 2
基因别名: TESK2
UniProt ID: (Human) Q96S53, (Rat) Q924U5, (Mouse) Q8VCT9
Entrez Gene ID: (Human) 10420, (Rat) 170908, (Mouse) 230661