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产品信息
PA5-62255
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2648388
产品详细信息
Immunogen sequence: SLKGGLSQQG LKPSLKVEPQ NHFSSFKYSG NAVVESYSVL GNCRPSDPYS MNSVYSYHSY YAQPSLTSVN GFHSKYALPS FSYYGFPSSN PVFPSQFLGP GAWGHSGSSG SFEKKPDLH
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 88%.
靶标信息
TET3, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and is most abundantly expressed in hematopoietic cells. Unlike the related TET2 protein, mutations in TET3 have not been observed in any myeloid malignancies. TET3 has been shown to be involved in the demethylation of zygotic DNA before the first mitosis and has been suggested to be involved in the epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal cloning.
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生物信息学
蛋白别名: Methylcytosine dioxygenase TET3; MGC22014; probable methylcytosine dioxygenase TET3; putative methylcytosine dioxygenase; tet oncogene family member 3
基因别名: hCG_40738; KIAA0401; TET3
UniProt ID: (Human) O43151
Entrez Gene ID: (Human) 200424
