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Sequence of this protein is as follows: MERPDGLGAA AGGARLSSLP QAAYGPAPPL CHTPAATAAA EFQPPYFPPP YPQPPLPYGQ APDAAAAFPH LAGDPYGGLA PLAQPQPPQA AWAAPRAAAR AHEEPPGLLA PPARALGLDP RRDYATAVPR LLHGLADGAH GLADAPLGLP GLAAAPGLED LQAMDEPGMS LLDQSVIKKV PIPSKASSLS ALSLAKDSLV GGITNPGEVF CSVPGRLSLL SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRCLRERLEK IGLNLPAGRR KAANVTLLTS LVEGEAVHLA RDFGYVCETE FPAKAAAEYL CRQHADPGEL HSRKSMLLAA KQICKEFADL MAQDRSPLGN SRPALILEPG VQSCLTHFSL ITHGFGGPAI CAALTAFQNY LLESLKGLDK MFLSSVGSGH GETKASEKDA KHRK
TFAP2E is the sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 epsilon may play a role in the development of the CNS and in cartilage differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activating enhancer-binding protein 2-epsilon; adaptor-related protein complex 2, epsilon subunit; AP2-epsilon; MGC49007; TFAP2E; transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon); Transcription factor AP-2-epsilon
基因别名: AP2E; TFAP2E
UniProt ID: (Human) Q6VUC0
Entrez Gene ID: (Human) 339488
分子生物学功能:
general transcription factor