Search Thermo Fisher Scientific
Immunogen sequence: IVTQWQPRN CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN PLTDTVPIHS WIHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL VGLLEKHFFP KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV KDKFNEALDI MNRAVSSNVG AYMQPGAREN IAYLTHTERR KDFQYEAMQE RREAENMAQR GIGVAASSVP MNFKDLIETK AEEHNIVFMP VIGKRHEGKQ LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK (492-837 aa encoded by BC033080 )
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Septin and tuftelin-interacting protein 1; STIP-1; Tuftelin-interacting protein 11; tuftelin-interacting protein 33; Tuftelin-interacting protein 39; tuftelin-interacting protein, 39 kD
基因别名: 2810002G02Rik; AF097181; AW046167; bK445C9.6; hNtr1; HSPC006; NTR1; Spp382; Srr1; STIP; TFIP11; TIP33; TIP39
UniProt ID: (Human) Q9UBB9, (Rat) Q5U2Y6, (Mouse) Q9ERA6
Entrez Gene ID: (Human) 24144, (Rat) 288718, (Mouse) 54723
分子生物学功能:
RNA splicing factor