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Immunogen sequence: MSLSHLYRDG EGRIDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT YGVWAERDSD DERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSDD EEKPVKQDDF PKDFGPRKLK TGGNFKPSQK GFAGGTKSFM; Positive Samples: LO2, HeLa, A-431, MCF-7, HT-1080, Mouse brain, Mouse liver; Cellular Location: Cytoplasm, Nucleus
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Septin and tuftelin-interacting protein 1; STIP-1; Tuftelin-interacting protein 11; tuftelin-interacting protein 33; Tuftelin-interacting protein 39; tuftelin-interacting protein, 39 kD
基因别名: 2810002G02Rik; AF097181; AW046167; bK445C9.6; hNtr1; HSPC006; NTR1; Spp382; Srr1; STIP; TFIP11; TIP33; TIP39
UniProt ID: (Human) Q9UBB9, (Mouse) Q9ERA6
Entrez Gene ID: (Human) 24144, (Mouse) 54723
分子生物学功能:
RNA splicing factor