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TGFBR1 Antibody (PA5-95863) in WB
Western blot analysis of TGFBR1 in extracts of various cell lines. Samples were incubated with TGFBR1 Polyclonal antibody (Product # PA5-95863) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-95863
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 161-179 of human TGF beta Receptor I (TGFBR1) (NP_004603.1).
偶联物
Unconjugated
形式
Liquid
浓度
1.41 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807665
产品详细信息
Positive Samples: HeLa, SW480, 22Rv1, mouse brain, rat brain
Immunogen sequence: EEDPSLDRPF ISEGTTLKD
靶标信息
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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