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Immunogen sequence: MSDSDLGED EGLLSLAGKR KRRGNLPKES VKILRDWLYL HRYNAYPSEQ EKLSLSGQTN LSVLQICNWF INARRRLLPD MLRKDGKDPN QFTISRRGGK ASDVALPRGS SPSVLAVSVP APTNVLSLSV CSMPLHSGQG EKPAAPFPRG ELESPKPLVT PGSTLTLLTR AEAGSPTGGL FNTPPPTPPE QDKEDFSSFQ LLVEVALQRA AEMELQKQQD PSLPLLHTPI PLVSENPQ (1-237 aa encoded by BC012816)
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5'-TG-3' interacting factor 2; 5'-TG-3'-interacting factor 2; Homeobox protein TGIF2; OTTHUMP00000030849; TALE family homeobox; TGF(beta)-induced transcription factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2; TGFB-induced factor 2 (TALE family homeobox); TGFB-induced factor homeobox 2; transcription growth factor-beta-induced factor 2
基因别名: 4921501K24; 5730599O09Rik; C80753; C81206; TGIF2
UniProt ID: (Human) Q9GZN2, (Mouse) Q8C0Y1
Entrez Gene ID: (Human) 60436, (Mouse) 228839