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产品信息
PA5-95256
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human TGM2 (7-34aa LERCDLELETNGRDHHTADLCREKLVVR).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807060
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase 2; TGase C; TGase H; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG
基因别名: G[a]h; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas
UniProt ID: (Human) P21980, (Rat) Q9WVJ6, (Mouse) P21981
Entrez Gene ID: (Human) 7052, (Rat) 56083, (Mouse) 21817
phospholipase C-activating G-protein coupled receptor signaling pathway
peptide cross-linking
negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
branching involved in salivary gland morphogenesis
salivary gland cavitation
blood vessel remodeling
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
protein homooligomerization
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
G-protein coupled receptor signaling pathway
