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TGM2 Antibody (MA5-38288) in WB
Western Blot analysis of TGM2 using TGM2 Monoclonal Antibody (Product # MA5-38288) at 1:2,000. Positive WB detected in: U87 whole cell lysate. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 78, 62, 39 kDa. Observed band size: 78 kDa
产品信息
MA5-38288
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7E1
抗原
A synthesized peptide derived from human TGM2
偶联物
形式
Liquid
浓度
0.48 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2898203
产品详细信息
This antibody has been tested in direct-ELISA
靶标信息
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C polypeptide, protein-glutamine-gamma-glutamyltransferase; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; RP5-1054A22.2; TG(C); TG2; TGase C; TGase H; TGase II; TGase-2; TGase-H; Tissue transglutaminase; Tissue type transglutaminase; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG
基因别名: TG(C); TGC; TGM2
UniProt ID: (Human) P21980
Entrez Gene ID: (Human) 7052
phospholipase C-activating G-protein coupled receptor signaling pathway
peptide cross-linking
negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
branching involved in salivary gland morphogenesis
salivary gland cavitation
