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产品信息
PA5-48604
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 357-385 amino acids of human TIAM2
偶联物
形式
Liquid
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2634061
靶标信息
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; T-cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2
基因别名: 3000002F19Rik; KIAA2016; mKIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5, (Mouse) Q6ZPF3
Entrez Gene ID: (Human) 26230, (Mouse) 24001
