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TIMP3 Antibody (PA5-78423) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of TIMP3 was performed in DIV10 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: TIMP3 Polyclonal Antibody (Product # PA5-78423) diluted at 1:500. Red: alpha Tubulin, stained by alpha Tubulin antibody. Blue: Fluoroshield with DAPI.
产品信息
PA5-78423
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human TIMP3. The exact sequence is proprietary.
偶联物
Unconjugated
形式
Liquid
浓度
0.51 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 0.1M glycine, 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736704
产品详细信息
Positive Control: mouse kidney
Predicted Reactivity: Human (100%), Rat (97%), Xenopus laevis (83%), Dog (100%), Rabbit (97%), Chicken (82%), Sheep (100%), Rhesus Monkey (100%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a member of the tissue inhibitor of metalloproteinases gene family. It functions to inhibit the activity of matrix metalloproteinases (MMP) which degrade components of the extracellular matrix. TIMP3 is expressed upon mitogenic stimulation. It binds irreversibly to zinc-dependent MMPs and inactivates them by binding to their catalytic zinc cofactor. Other functions of TIMP3 include nervous system development, tissue regeneration, and visual perception. In humans, the gene encoding TIMP3 is located on chromosome 22.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Metalloproteinase inhibitor 3; MIG-5 protein; Protein MIG-5; TIMP 3; TIMP-3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); Tissue inhibitor of metalloproteinases 3
基因别名: HSMRK222; K222; K222TA2; SFD; Sun; Timp-3; TIMP3
UniProt ID: (Human) P35625, (Mouse) P39876
Entrez Gene ID: (Human) 7078, (Rat) 25358, (Mouse) 21859
platelet degranulation
central nervous system development
aging
visual perception
response to mechanical stimulus
response to hormone
response to organic substance
tissue regeneration
response to amino acid
response to estrogen
negative regulation of membrane protein ectodomain proteolysis
response to folic acid
negative regulation of ERK1 and ERK2 cascade
cellular response to organic substance
positive regulation of TRAIL-activated apoptotic signaling pathway
negative regulation of metalloendopeptidase activity
negative regulation of endopeptidase activity
response to organic cyclic compound
response to cytokine
negative regulation of catalytic activity
negative regulation of proteolysis
negative regulation of peptidase activity
