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Immunogen sequence: MVSSAKDTVA TQLSEAVDAT RGAVQSGVDK TKSVVTGGVQ SVMGSRLGQM VLSGVDTVLG KSEEWADNHL PLTDAELARI ATSLDGFDVA SVQQQRQEQS YFVRLGSLSE RLRQHAYEHS LGKLRATKQR AQEALLQLSQ VLSLMETVKQ GVDQKLVEGQ EKLHQMWLSW NQKQLQGPEK EPPKPEQVES RALTMFRDIA QQLQATCTSL GSSIQGLPTN VKDQVQQARR QVEDLQATFS SIHSFQDLSS SILAQSRERV ASAREALDHM VEYVAQNTPV TWLVGPFAPG ITEKAPEEKK; Positive Samples: HeLa, Jurkat, SW480, 293T; Cellular Location: Cytoplasm, Cytoplasmic side, Endosome membrane, Lipid droplet, Peripheral membrane protein
TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome to Golgi transport. This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; mannose-6-phosphate receptor binding protein 1; Mannose-6-phosphate receptor-binding protein 1; MGC11117; MGC2012; Perilipin-3; Placental protein 17; PP17; tail-interacting protein, 47 kD; testicular tissue protein Li 114
基因别名: 1300012C15Rik; M6PRBP1; PLIN3; PP17; TIP47
UniProt ID: (Human) O60664, (Mouse) Q9DBG5
Entrez Gene ID: (Human) 10226, (Mouse) 66905
分子生物学功能:
scaffold/adaptor protein