Proteintech

TLK2 Polyclonal Antibody

TLK2 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 7

TLK2 Antibody (13979-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using (Product # 13979-1-AP) (TLK2 antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TLK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

产品信息

13979-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:200

免疫细胞化学 (ICC/IF)

1:20-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

TLK2 Fusion Protein Ag5022 (512-831 aa encoded by BC044925)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.17 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: DHPTLNDRY LLLHLLGRGG FSEVYKAFDL TEQRYVAVKI HQLNKNWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY FSLDTDSFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIIM QIVNALKYLN EIKPPIIHYD LKPGNILLVN GTACGEIKIT DFGLSKIMDD DSYNSVDGME LTSQGAGTYW YLPPECFVVG KEPPKISNKV DVWSVGVIFY QCLYGRKPFG HNQSQQDILQ ENTILKATEV QFPPKPVVTP EAKAFIRRCL AYRKEDRIDV QQLACDPYLL PHIRKSVSTS SPAGAAIAST SGASNNSSSN (512-831 aa encoded by BC044925)

靶标信息

TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

仅用于科研。不用于诊断过程。未经明确授权不得转售。