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产品信息
MA5-32590
产品规格
种属反应
Rat,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM10-88
抗原
Recombinant protein within Human TLR5 aa 238-424
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809867
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ10052; MGC126430; MGC126431; RP11-239E10.1; systemic lupus erythematosus susceptibility 1; Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3
基因别名: MELIOS; SLE1; SLEB1; TIL3; TLR5
UniProt ID: (Human) O60602, (Mouse) Q9JLF7
Entrez Gene ID: (Human) 7100, (Mouse) 53791, (Rat) 289337
positive regulation of cytokine production
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
signal transduction
positive regulation of interleukin-8 production
positive regulation of toll-like receptor signaling pathway
toll-like receptor 5 signaling pathway
defense response to bacterium
innate immune response
positive regulation of nitric oxide biosynthetic process
regulation of cytokine secretion
male gonad development
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
defense response to Gram-negative bacterium
