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产品信息
H00010333-M06
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1A5
抗原
TLR6 (NP_006059, 201 a.a. approximately 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGST LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS
靶标信息
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD antigen 286; CD286; Toll-like receptor 6
基因别名: CD286; TLR6
UniProt ID: (Human) Q9Y2C9
Entrez Gene ID: (Human) 10333
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
toll-like receptor 6 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
innate immune response
positive regulation of interleukin-6 biosynthetic process
interleukin-1 beta secretion
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
positive regulation of NLRP3 inflammasome complex assembly
