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Immunogen sequence: ASLIFIFTL FMVSCKVFLT ATHSHSSPFD ALEGYICPVL FGSACGGDHH HDNHGGSHSG GGPGAQHSAM PAKSKEELSE GSRKKKAKKA D (210-299 aa encoded by BC001195)
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 27 kDa sarcoplasmic reticulum protein; Mitsugumin-33A; Mitsugumin33A; sarcoplasmic reticulum protein 27; SPR-27; tmem38a {ECO:0000250|UniProtKB:Q3TMP8}; Transmembrane protein 38A; TRIC-A; TRICA; Trimeric intracellular cation channel type A
基因别名: 1110001E17Rik; AI413399; mg33a; RGD1307901; Srp-27; TMEM38A; TRIC-A; TRICA
UniProt ID: (Human) Q9H6F2, (Mouse) Q3TMP8, (Rat) A6ZIQ8
Entrez Gene ID: (Human) 79041, (Mouse) 74166, (Rat) 306327
分子生物学功能: ion channel