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TMPRSS6 Antibody (PA5-143873) in WB
Western blot analysis of TMPRSS6 using TMPRSS6 antibody (Product # PA5-143873). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: human HCCT tissue lysates; Lane 2: rat brain tissue lysates; Lane 3: mouse brain tissue lysates; Lane 4: rat liver tissue lysates; Lane 5: mouse liver tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA f... View More
产品信息
PA5-143873
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human Matriptase 2/TMPRSS6 recombinant protein (Position: M1-Q759).
偶联物
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_3075087
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
靶标信息
TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: matriptase 2; Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; Transmembrane protease serine 6; transmembrane protease, serine 6; transmembrane serine protease 6; type II transmembrane serine protease 6
基因别名: 1300008A22Rik; IRIDA; TMPRSS6; UNQ354/PRO618
UniProt ID: (Human) Q8IU80, (Mouse) Q9DBI0
Entrez Gene ID: (Human) 164656, (Rat) 315388, (Mouse) 71753
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
proteolysis
cellular iron ion homeostasis
extracellular matrix organization
negative regulation of BMP signaling pathway
membrane protein proteolysis
intracellular signal transduction
fibrinolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
self proteolysis
biological_process
