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TNFR2 Antibody (MA5-29837) in Neu
Mouse TNFR2 Inhibition of Mouse TNFalpha-induced Cytotoxicity and Neutralization by TNFR2 Recombinant Rabbit Monoclonal Antibody (R204). Recombinant Mouse TNFRSF1B inhibits Recombinant Mouse TNFalpha induced cytotoxicity in the L-929 mouse fibroblast cell line. Inhibition of Recombinant Mouse TNFalpha (0.5 ng/mL) activity elicited by Recombinant Mouse TNFR2 (25 ng/mL) is neutralized by increasing concentrations of TNFR2 Recombinant Rabbit Monoclonal Antibody (R204) (Product # MA5-29837). The ND50is typically 16-50 ng/mL in the presence of ... View More
产品信息
MA5-29837
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
R204
抗原
Recombinant Mouse TNFR2/TNFRSF1B/CD120b protein (Met1-Gly258)
偶联物
形式
Liquid
浓度
2.64 mg/mL
纯化类型
Protein A
保存液
Histidine/arginine, pH 6, with 120mM NaCl, 0.02% Tween 80
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2785656
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse TNFR2/TNFRSF1B/CD120b.
靶标信息
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD120b; p75; p75 TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TNF receptor beta chain; TNF-R2; TNF-RII; TNFR; TNFR II; TNFR-II; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II
基因别名: CD120b; p75; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr-2; Tnfr2; TNFR80; TNFRII; Tnfrsf1b
UniProt ID: (Mouse) P25119
Entrez Gene ID: (Mouse) 21938
inflammatory response
immune response
cell surface receptor signaling pathway
cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
programmed cell death
tumor necrosis factor-mediated signaling pathway
negative regulation of inflammatory response
RNA destabilization
positive regulation of membrane protein ectodomain proteolysis
cellular response to lipopolysaccharide
extrinsic apoptotic signaling pathway
