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Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD267; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; Transmembrane activator and CAML interactor; Tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
基因别名: 1200009E08Rik; Taci; Tnfrsf13b
UniProt ID: (Mouse) Q9ET35
Entrez Gene ID: (Rat) 103693341, (Mouse) 57916