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产品信息
24999-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TNFRSF6B Fusion Protein Ag19781 (1-300 aa encoded by BC017065)
偶联物
形式
Liquid
浓度
0.47 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MRALEGPGL SLLCLVLALP ALLPVPAVRG VAETPTYPWR DAETGERLVC AQCPPGTFVQ RPCRRDSPTT CGPCPPRHYT QFWNYLERCR YCNVLCGERE EEARACHATH NRACRCRTGF FAHAGFCLEH ASCPPGAGVI APGTPSQNTQ CQPCPPGTFS ASSSSSEQCQ PHRNCTALGL ALNVPGSSSH DTLCTSCTGF PLSTRVPGAE ECERAVIDFV AFQDISIKRL QRLLQALEAP EGWGPTPRAG RAALQLKLRR RLTELLGAQD GALLVRLLQA LRVARMPGLE RSVRERFLPV H (1-300 aa encoded by BC017065)
靶标信息
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DcR3; Decoy receptor 3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; Decoy receptor for Fas ligand; hCG_2044836; M68; OTTHUMP00000031583; Tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily member 6b, decoy; tumor necrosis factor receptor superfamily, member 6b, decoy
基因别名: DCR3; DJ583P15.1.1; M68; M68E; TNFRSF6B; TR6; UNQ186/PRO212
UniProt ID: (Human) O95407
Entrez Gene ID: (Human) 8771
