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Application
FIGURE: 1 / 1
TPM3 Antibody (PA5-29005) in WB
Oncology reports 2019 -
Figure 5. Effect of miR-183-5p.1 on the expression of TPM2 and TPM3 in GC AGS cells. (A and B) miR-183-5p.1 mimics downregulated the expression of TPM2 and TPM3 as determined by western blotting. (C and D) miR-183-5p.1 inhibitors promoted the expression of TPM2 and TPM3 as detected by western blotting. Results are presented as the mean +- standard error of the mean (n=3). ***P<0.001. GC, gastric cancer; miR... View More
Product Details
PA5-29005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human Tropomyosin 3 Recombinant protein.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546481
Product Specific Information
Recommended positive controls: 293T.
Predicted reactivity: Mouse (100%), Rat (99%), Zebrafish (83%), Dog (93%), Pig (100%), Chicken (84%), Rhesus Monkey (93%), Bovine (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TPM3 (tropomyosin 3) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-tropomyosin, slow skeletal; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; Gamma-tropomyosin; heat-stable cytoskeletal protein 30 kDa; hTM5; tropomyosin; Tropomyosin alpha-3 chain; tropomyosin gamma; Tropomyosin-3; Tropomyosin-5
Gene Aliases: CAPM1; CFTD; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPM3; TPMsk3; TRK
UniProt ID: (Human) P06753
Entrez Gene ID: (Human) 7170
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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