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NeoBiotechnologies
TPO (Thyroid Peroxidase) (Thyroid Marker) Recombinant Rabbit Monoclonal Antibody (TPO/3813R)
产品信息
7173-RBM13-P0
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
TPO/3813R
抗原
Recombinant fragment of human TPO (around aa 685-804).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Wet ice
靶标信息
Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
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生物信息学
蛋白别名: EC 1.11.1; thyroid microsomal antigen; Thyroid peroxidase; thyroperoxidase; TPO; TPXEC 1.11.1.8
基因别名: MSA; TDH2A; TPO; TPX
UniProt ID: (Human) P07202
Entrez Gene ID: (Human) 7173
