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产品信息
14404-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TRAF3IP1 Fusion Protein Ag5677 (276-626 aa encoded by BC059174)
偶联物
形式
Liquid
浓度
0.24 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DRDRRRVKN GEHSWDLDRE KNREHDKPEK KSASSGEMSK KLSDGTFKDS KAETETEIST RASKSLTTKT SKRRSKNSVE GDSTSDAEGD AGPAGQDKSE VPETPEIPNE LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R (276-626 aa encoded by BC059174)
靶标信息
Tumor necrosis factor receptor (TNFR) superfamily members transmit signals regulating proliferation, differentiation and apoptosis in various types of cells. TNFR-associated factors (TRAFs) are a family of proteins that were initially discovered as downstream signal transducers of the TNFR superfamily. TRAF3 contains an N-terminal ring finger/zinc finger region that is thought to be essential for downstream signaling. MIP-T3 is associated with TRAF3. MIP-T3 binds to taxol-stabilized microtubules and to tubulin in vitro, and MIP-T3 recruits TRAF3 to microtubules when both proteins are overexpressed. The MIP-T3/TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3. This interaction may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: interleukin 13 receptor alpha 1-binding protein-1; Interleukin-13 receptor alpha 1-binding protein 1; Intraflagellar transport protein 54 homolog; microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3; MIP-T3; TNF receptor-associated factor 3 interacting protein 1; TRAF3-interacting protein 1
基因别名: 3930402D05Rik; AU041749; IFT54; MIP-T3; MIPT3; SLSN9; TRAF3IP1
UniProt ID: (Human) Q8TDR0, (Rat) Q5XIN3, (Mouse) Q149C2
Entrez Gene ID: (Human) 26146, (Rat) 363286, (Mouse) 74019
neural tube patterning
embryonic camera-type eye development
negative regulation of interferon-beta production
embryonic heart tube development
post-anal tail morphogenesis
intraciliary transport
cilium assembly
embryonic digit morphogenesis
negative regulation of defense response to virus
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
morphogenesis of a polarized epithelium
kidney development
negative regulation of protein phosphorylation
negative regulation of protein complex assembly
negative regulation of type I interferon production
regulation of microtubule cytoskeleton organization
negative regulation of transcription from RNA polymerase II promoter
negative regulation of tyrosine phosphorylation of Stat6 protein
regulation of DNA binding
