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            Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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            • Primary Antibodies ›
            • TRAP220 Antibodies

            Invitrogen

            TRAP220 Recombinant Rabbit Monoclonal Antibody (BLR037F)

            查看其他22个TRAP220抗体

            促销

            促销

            Invitrogen 17万+抗体限时买二赠一, 靶点广,灵活用!. 更多

            说明书
            实验方案
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            货号 MA5-44269
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            Price (CNY)
            4,786.00
             
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            Cite TRAP220 Recombinant Rabbit Monoclonal Antibody (BLR037F)

            TRAP220 Recombinant Rabbit Monoclonal Antibody (BLR037F)

            产品信息

            MA5-44269

            应用
            建议稀释比
            已发表文章

            免疫印迹 (WB)

            1:1,000
            -

            免疫组化(石蜡) (IHC (P))

            1:100-1:500
            -

            免疫细胞化学 (ICC/IF)

            1:100-1:500
            -

            免疫沉淀 (IP)

            20 µL/1 mg lysate
            -
            产品规格

            种属反应

            Human

            宿主/亚型

            Rabbit / IgG

            Expression System

            HEK293 cells

            分类

            Recombinant Monoclonal

            类型

            Antibody

            克隆号

            BLR037F

            抗原

            Peptide representing a region between residue 1550 and the C-terminus (residue 1581) of human mediator complex subunit 1
            查看免疫原

            偶联物

            Unconjugated

            形式

            Liquid

            浓度

            100 µg/mL

            纯化类型

            purified

            保存液

            BBS, pH 8.2, with 0.1% BSA

            内含物

            0.09% sodium azide

            保存条件

            4°C

            运输条件

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2926399

            产品详细信息

            Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

            靶标信息

            Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

            仅用于科研。不用于诊断过程。未经明确授权不得转售。

            篇参考文献 (0)

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            引用该产品

            生物信息学

            蛋白别名: Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Mediator of RNA polymerase II transcription subunit 1; p53 regulatory protein RB18A; PBP; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPAR-binding protein; PPARG binding protein; PPRB; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; Thyroid receptor-interacting protein 2; TR-interacting protein 2; Trap220; TRIP-2; vitamin D receptor-interacting protein 230 kD; Vitamin D receptor-interacting protein complex component DRIP205

            查看更多 收起

            基因别名: ARC205; CRSP1; CRSP200; DRIP205; DRIP230; MED1; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2

            查看更多 收起

            UniProt ID: (Human) Q15648

            查看更多 收起

            Entrez Gene ID: (Human) 5469

            查看更多 收起

            功能

            RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter binding RNA polymerase II transcription cofactor activity chromatin binding transcription cofactor activity transcription coactivator activity receptor activity protein binding transcription factor binding ligand-dependent nuclear receptor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity chromatin DNA binding nuclear hormone receptor binding mediator complex binding vitamin D receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding thyroid hormone receptor binding LBD domain binding ubiquitin protein ligase activity RNA metabolism protein nucleic acid metabolism protein general transcription factor

            参与通路

            negative regulation of transcription from RNA polymerase II promoter cell morphogenesis angiogenesis liver development embryonic placenta development lens development in camera-type eye thyroid hormone mediated signaling pathway ventricular trabecula myocardium morphogenesis retinal pigment epithelium development regulation of transcription from RNA polymerase I promoter transcription initiation from RNA polymerase II promoter thyroid hormone generation androgen biosynthetic process brain development lactation positive regulation of gene expression negative regulation of keratinocyte proliferation protein ubiquitination keratinocyte differentiation monocyte differentiation intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway organ regeneration positive regulation of intracellular estrogen receptor signaling pathway positive regulation of protein import into nucleus, translocation positive regulation of mammary gland epithelial cell proliferation embryonic heart tube development embryonic hindlimb morphogenesis embryonic hemopoiesis peroxisome proliferator activated receptor signaling pathway cellular response to hepatocyte growth factor stimulus megakaryocyte development mRNA transcription from RNA polymerase II promoter negative regulation of apoptotic process cellular lipid metabolic process fat cell differentiation positive regulation of keratinocyte differentiation positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter erythrocyte development enucleate erythrocyte development regulation of cell cycle positive regulation of interferon-gamma-mediated signaling pathway mammary gland branching involved in thelarche mammary gland branching involved in pregnancy epithelial cell proliferation involved in mammary gland duct elongation positive regulation of G0 to G1 transition ERK1 and ERK2 cascade regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to steroid hormone stimulus cellular response to thyroid hormone stimulus positive regulation of receptor activity positive regulation of hepatocyte proliferation regulation of RNA biosynthetic process
            It has to be done as per old AB suggested Products section.
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