Invitrogen

TREM2 Polyclonal Antibody

TREM2 Antibody in Immunocytochemistry (ICC/IF)

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TREM2 Antibody (PA5-87933) in ICC/IF

Immunofluorescence analysis of TREM2 in NIH/3T3 cells. Samples were incubated with TREM2 Polyclonal antibody (Product # PA5-87933) using a dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.

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产品信息

PA5-87933

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

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免疫细胞化学 (ICC/IF)

1:50-1:200

in situ PLA (PLA)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 19-161 of human TREM2 (NP_0618381)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.11 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2804516

产品详细信息

Immunogen sequence: HNTTVFQGVA GQSLQVSCPY DSMKHWGRRK AWCRQLGEKG PCQRVVSTHN LWLLSFLRRW NGSTAITDDT LGGTLTITLR NLQPHDAGLY QCQSLHGSEA DTLRKVLVEV LADPLDHRDA GDLWFPGESE SFEDAHVEHS ISR

Positive Samples: Mouse brain; Cellular Location: Cell membrane, Single-pass type I membrane protein

靶标信息

TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells.

Oxidative medicine and cellular longevity

de Sousa JAC,Azul FVCS,de Araújo AB,Tomé RC,Silva FRM,de Vasconcelos SMM,Rios FJ,Leal LKAM

PA5-87933 was used in Western Blotting to demonstrate the potent anti-inflammatory properties of EPI in microglial cells.

Tue May 09 00:00:00 EDT 2023

TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair.

Journal of neuroinflammation

Xu J,Zhang L,Li M,He X,Luo J,Wu R,Hong Z,Zheng H,Hu X

PA5-87933 was used in Western Blotting to reveal a novel regenerative role of PE in white matter injury after stroke, which is mediated by upregulation of TREM2 and microglia-derived factor for oligodendrocytes regeneration.

Sat Feb 25 00:00:00 EST 2023

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.

Molecular neurodegeneration

Zhao P,Xu Y,Jiang LL,Fan X,Ku Z,Li L,Liu X,Deng M,Arase H,Zhu JJ,Huang TY,Zhao Y,Zhang C,Xu H,Tong Q,Zhang N,An Z

PA5-87933 was used in Flow cytometry/Cell sorting to reveal the molecular mechanisms of LILRB2-mediated inhibition of TREM2 signaling in microglia and demonstrate a novel approach of enhancing TREM2-mediated microglia functions by blocking LILRB2-ligand interactions.

Sat Jun 18 00:00:00 EDT 2022

生物信息学

蛋白别名: OTTHUMP00000039771; soluble TREM 2; soluble TREM2; sTREM 2; sTREM2; TREM; TREM-2; Triggering receptor expressed on monocytes 2; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c

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基因别名: TREM-2; TREM2; Trem2a; Trem2b; Trem2c

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UniProt ID: (Human) Q9NZC2, (Mouse) Q99NH8

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Entrez Gene ID: (Human) 54209, (Rat) 301227, (Mouse) 83433

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功能

lipopolysaccharide binding receptor activity peptidoglycan binding lipoteichoic acid binding scaffold protein binding transmembrane signaling receptor activity protein binding immunoglobulin receptor superfamily

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