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产品信息
24876-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TREX1 Fusion Protein Ag18325 (1-369 aa encoded by BC023630)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGPGARRQG RIVQGRPEMC FCPPPTPLPP LRILTLGTHT PTPCSSPGSA AGTYPTMGSQ ALPPGPMQTL IFFDMEATGL PFSQPKVTEL CLLAVHRCAL ESPPTSQGPP PTVPPPPRVV DKLSLCVAPG KACSPAASEI TGLSTAVLAA HGRQCFDDNL ANLLLAFLRR QPQPWCLVAH NGDRYDFPLL QAELAMLGLT SALDGAFCVD SITALKALER ASSPSEHGPR KSYSLGSIYT RLYGQSPPDS HTAEGDVLAL LSICQWRPQA LLRWVDAHAR PFGTIRPMYG VTASARTKPR PSAVTTTAHL ATTRNTSPSL GESRGTKDLP PVKDPGALSR EGLLAPLGLL AILTLAVATL YGLSLATPGE (1-369 aa encoded by BC023630)
靶标信息
Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III; Three-prime repair exonuclease 1
基因别名: AGS1; CRV; DRN3; HERNS; TREX1
UniProt ID: (Human) Q9NSU2
Entrez Gene ID: (Human) 11277
