Invitrogen

TRF1 Monoclonal Antibody (3H11)

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TRF1 Antibody (MA1-46089) in WB

International journal of molecular sciences 2021 - Figure 3 Toxic concentrations of antidepressants promote DNA fragmentation of treated cells. GC-1 spg and GC-2 spd cells were treated with antidepressants for 48 and 96 h. The TUNEL labeling system to detect the DNA damage was then applied ( A , C ) and the level of TRF1, TRF2 proteins were controlled by Western blot technique. Representative blots ( B , D ) and photos of TUNEL cells are shown (magnificatio... View More

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产品信息

MA1-46089

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:100-1:2,000

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免疫组化 (IHC)

1:10-1:500

免疫细胞化学 (ICC/IF)

1:10-1:500

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

3H11

抗原

Human TRF1 protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1018574

产品详细信息

Suggested positive control: antigen standard for TERF1 (transient overexpression lysate).

靶标信息

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects.

International journal of molecular sciences

Sołek P,Mytych J,Tabęcka-Łonczyńska A,Koziorowski M

MA1-46089 was used in Western Blot to suggest that antidepressants promote a telomere-focused DNA damage response in germ cell lines, which broadens the established view of antidepressants' and neuroleptic drugs' toxicity and points to the need for further research in this topic with the use of in vivo models and human samples.

Mon Nov 01 00:00:00 EDT 2021

Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes.

Experimental cell research

Mytych J,Wos I,Solek P,Koziorowski M

MA146089 was used in western blot to show that ROS-induced DNA damage reduces metabolic activity, inhibits proliferation, and induces cell cycle arrest followed by activation of p16-, p21-, and p27- mediated DNA damage response pathways, premature senescence, and apoptosis induction

Sun Jan 15 00:00:00 EST 2017

Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes.

Toxicology in vitro : an international journal published in association with BIBRA

Mytych J,Romerowicz-Misielak M,Koziorowski M

MA146089 was used in western blot to report the effects of long-term lipopolysaccharide exposure on monocytes

Tue Aug 01 00:00:00 EDT 2017

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Shaw G,Morse S,Ararat M,Graham FL

MA1-46089 was used in immunocytochemistry to transform human neuronal cells by means of human adenovirus and compare these cell lines with HEK 293 cells

Sat Jun 01 00:00:00 EDT 2002

生物信息学

蛋白别名: FLJ41416; NIMA-interacting protein 2; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; Telomeric repeat-binding factor 1; TTAGGG repeat-binding factor 1

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基因别名: hTRF1-AS; PIN2; t-TRF1; TERF1; TRBF1; TRF; TRF1

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UniProt ID: (Human) P54274

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Entrez Gene ID: (Human) 7013

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功能

DNA binding double-stranded telomeric DNA binding telomerase activity protein binding DNA binding, bending telomeric DNA binding protein homodimerization activity ubiquitin binding G-rich strand telomeric DNA binding

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