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Invitrogen
TRIM72 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-63039
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2648948
产品详细信息
Immunogen sequence: LEAHVEAKEP RALRSPERRP TRIGLYLSFG DGVLSFYDAS DADALVPLFA FHERLPRPVY PFFDVCWHDK GKNAQPLLLV GPE
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
靶标信息
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mg53; mitsugumin 53; Mitsugumin-53; TRIM72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; Tripartite motif-containing protein 72
基因别名: MG53; TRIM72
UniProt ID: (Human) Q6ZMU5
Entrez Gene ID: (Human) 493829
plasma membrane repair
muscle system process
exocytosis
muscle contraction
muscle organ development
negative regulation of myotube differentiation
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of insulin receptor signaling pathway
protein homooligomerization
