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TRIP10 Antibody (PA5-102992) in ICC/IF
Immunocytochemistry analysis of TRIP10 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with TRIP10 polyclonal antibody (Product # PA5-102992) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-102992
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TRIP10(Accession Q15642), corresponding to amino acid residues S296-P346.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852364
产品详细信息
Antibody detects endogenous levels of total TRIP10.
靶标信息
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cdc42 interacting protein-4; Cdc42-interacting protein 4; hSTP; Protein Felic; Salt tolerant protein; salt tolerator; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10
基因别名: AI646975; CIP4; HSTP; STOT; STP; TRIP-10; TRIP10
UniProt ID: (Human) Q15642, (Mouse) Q8CJ53, (Rat) P97531
Entrez Gene ID: (Human) 9322, (Mouse) 106628, (Rat) 116717
