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产品信息
PA5-121057
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1).
偶联物
形式
Liquid
浓度
1.19 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914629
产品详细信息
Positive test controls include: HepG2, HeLa, SKOV3, A673, 5637, Mouse kidney, Mouse heart, Mouse lung. The target is usually found in the following locations: Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Lysosome, cell cortex, cytoskeleton, perinuclear region, phagocytic cup.
Immunogen sequence: AKCLEGMKVA ANAVDPKNDS HVLIELHKSG FARPGDVEFE DFSQPMNRAP SDSSLGTPSD GRPELRGPGR SRTKRWPFGK KNKTVVTEDF SHLPPEQQRK RLQQQLEERS RELQKEVDQR EALKKMKDVY EKTPQMGDPA SLEPQIAETL SNIERLKLEV QKYEAWLAEA ESRVLSNRGD SLSRHARPPD PPASAPPDSS SNSASQDTKE SSEEPPSEES QDTPIYTEFD EDFEEEPTSP IGHCVAIYHF EGSSEGTISM AEGEDLSLME EDKGDGWTRV RRKEGGEGYV PTSYLRVTLN
靶标信息
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cdc42 interacting protein-4; Cdc42-interacting protein 4; hSTP; Protein Felic; Salt tolerant protein; salt tolerator; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10
基因别名: AI646975; CIP4; HSTP; STOT; STP; TRIP-10; TRIP10
UniProt ID: (Human) Q15642, (Mouse) Q8CJ53
Entrez Gene ID: (Human) 9322, (Mouse) 106628
