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产品信息
PA1-4139
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues E(239) C G G K M H L R E G E(250) of human Alien.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2081452
产品详细信息
PA1-4139 detects alien in human samples.
PA1-4139 has been successfully used in Western blot procedures.
The PA1- 4139 immunogen is a synthetic peptide corresponding to residues E(239) C G G K M H L R E G E(250) of human Alien. This sequence is 100% conserved in mouse, rat, and Drosophila.
靶标信息
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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生物信息学
蛋白别名: Alien homolog; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; JAB1-containing signalosome subunit 2; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
基因别名: ALIEN; COPS2; CSN2; SGN2; TRIP15
UniProt ID: (Human) P61201
Entrez Gene ID: (Human) 9318
negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
signal transduction
cell proliferation
cullin deneddylation
neuron differentiation
skeletal muscle cell differentiation
negative regulation of nucleic acid-templated transcription
