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Invitrogen
TSLP Receptor Polyclonal Antibody
高级验证
This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated.
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TSLP Receptor Antibody (PA5-47979) in IHC (P)
Immunohistochemical analysis of TSLP Receptor in immersion fixed paraffin-embedded sections of human lymph node. Samples were incubated in TSLP Receptor polyclonal antibody (Product # PA5-47979) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the pla... View More
产品信息
PA5-47979
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human TSLP R Val30-Phe232
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2577195
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytokine receptor CRL2 precusor; Cytokine receptor-like 2; Cytokine receptor-like factor 2; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; TSLP receptor; WI2-87105E3.1
基因别名: CRL2; CRLF2; CRLF2Y; ILXR; TSLPR
UniProt ID: (Human) Q9HC73
Entrez Gene ID: (Human) 64109
