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Immunogen sequence: MEDAKVYVAK VDCTAHSDVC SAQGVRGYPT LKLFKPGQEA VKYQGPRDFQ TLENWMLQTL NEEPVTPEPE VEPPSAPELK QGLYELSASN FELHVAQGDH FIKFFAPWCG HCKALAPTWE QLALGLEHSE TVKIGKVDCT QHYELCSGNQ VRGYPTLLWF RDGKKVDQYK GKRDLESLRE YVESQLQRTE TGATETVTPS EAPVLAAEPE ADKGTVLALT ENNFDDTIAE GITFIKFYAP WCGHCKTLAP TWEELSKKEF PGLAGVKIAE VDCTAERNIC SKYSVRGYPT LLLFRGGKKV SEHSGGRDLD SLHRFVLSQA KDEL; Positive Samples: HepG2, NCI-H460; Cellular Location: Endoplasmic reticulum lumen
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: endoplasmic reticulum protein ERp46; Endoplasmic reticulum resident protein 46; endothelial protein disulphide isomerase; ER protein 46; FLJ21353; FLJ90810; MGC3178; PC-TRP; Plasma cell-specific thioredoxin-related protein; protein disulfide isomerase family A, member 15; thiore; thioredoxin domain containing 5 (endoplasmic reticulum); Thioredoxin domain-containing protein 5; thioredoxin related protein; Thioredoxin-like protein p46
基因别名: AL022641; ENDOPDI; ERP46; HCC-2; HCC2; PC-TRP; PDIA15; STRF8; TLP46; TXNDC5; UNQ364; UNQ364/PRO700
UniProt ID: (Human) Q8NBS9, (Mouse) Q91W90
Entrez Gene ID: (Human) 81567, (Rat) 100362805, (Mouse) 105245
分子生物学功能:
chaperone