Invitrogen

Tenascin C Monoclonal Antibody (4C8MS)

Tenascin C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Tenascin C Antibody (MA5-16086) in IHC (P)

Immunohistochemical analysis of Tenascin C in formalin fixed paraffin embedded tissue section of mouse bone-tendon. Samples were incubated in Tenascin C monoclonal antibody (Product # MA5-16086) using a dilution of 1:25. The signal was detected using HRP-DAB detection method which followed counterstaining using hematoxylin. The antibody generated a very specific cytoplasmic, membrane and extra-cellular sign... View More

Tenascin C Antibody in Flow Cytometry (Flow)

Tenascin C Antibody in Immunohistochemistry (IHC)

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产品信息

MA5-16086

应用

建议稀释比

已发表文章

免疫印迹 (WB)

5 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:50

免疫组化（冰冻） (IHC (F))

Assay-Dependent

免疫细胞化学 (ICC/IF)

1:10-1:500

- -

流式细胞分析 (Flow)

1 µg per million cells

酶联免疫吸附实验 (ELISA)

Assay-Dependent

产品规格

种属反应

Cat, Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4C8MS

抗原

Recombinant human Tenascin C.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11152811

靶标信息

Tenascin is a high molecular weight, multifunctional, extracellular matrix glycoprotein expressed in association with mesenchymal-epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors (Erickson and Bourdon 1989). It has been described under a variety of names: cytotactin, hexabrachion protein, J1, myotendinous antigen (MI) and glioma mesenchymal extracellular matrix (GMEM). The tenascin molecule is a disulfide-linked hexamer. The expression of tenascin is associated with development and growth, both normal and pathological, whereas the distribution in normal adult tissue is restricted.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The Effects of Cold Water Immersion and Active Recovery on Molecular Factors That Regulate Growth and Remodeling of Skeletal Muscle After Resistance Exercise.

Frontiers in physiology

Peake JM,Markworth JF,Cumming KT,Aas SN,Roberts LA,Raastad T,Cameron-Smith D,Figueiredo VC

MA5-16086 was used in Immunohistochemistry to suggest that regular cold water immersion attenuates muscle hypertrophy independently of changes in factors that regulate myogenesis, proteolysis and extracellular matrix remodeling in muscle after exercise.

Mon Sep 28 00:00:00 EDT 2020

The Effects of Cold Water Immersion and Active Recovery on Molecular Factors That Regulate Growth and Remodeling of Skeletal Muscle After Resistance Exercise.

Frontiers in physiology

Peake JM,Markworth JF,Cumming KT,Aas SN,Roberts LA,Raastad T,Cameron-Smith D,Figueiredo VC

Mon Sep 28 00:00:00 EDT 2020

Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.

International journal of obesity (2005)

Becerril S,Rodríguez A,Catalán V,Méndez-Giménez L,Ramírez B,Sáinz N,Llorente M,Unamuno X,Gómez-Ambrosi J,Frühbeck G

MA5-16086 was used in Western Blotting to demonstrate the activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in adipocytes, suggesting an important role of this alarmin in the development of AT inflammation and fibrosis.

Wed Aug 01 00:00:00 EDT 2018

生物信息学

蛋白别名: Cytotactin; deafness, autosomal dominant 56; Glioma-associated-extracellular matrix antigen; GMEM; GP 150-225; Hexabrachion; hexabrachion (tenascin); JI; MGC144208; MGC144209; MGC167029; Myotendinous antigen; Neuronectin; Tenascin; Tenascin-C; tenascin-C additional domain 1; tenascin-C isoform 14/AD1/16; TN; TN-C; tnc

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基因别名: 150-225; AI528729; C130033P17Rik; cytotactin; DFNA56; GMEM; GP; HXB; JI; Ten; tenascin-C; TN; TN-C; TNC

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UniProt ID: (Human) P24821, (Mouse) Q80YX1

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Entrez Gene ID: (Human) 3371, (Rat) 116640, (Mouse) 21923

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功能

syndecan binding molecular_function fibronectin binding extracellular matrix protein extracellular matrix structural protein

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